IBM and AMD have announced a new collaboration to provide advanced artificial intelligence infrastructure to Zyphra, an open-source AI research and product company based in San Francisco. The agreement will see IBM deliver a large cluster of AMD Instinct MI300X GPUs on IBM Cloud for Zyphra’s use in training multimodal foundation models.
Zyphra recently completed a Series A financing round, reaching a $1 billion valuation. The company aims to establish itself as a leader in open-source superintelligence research, focusing on neural network architectures, long-term memory, and continual learning.
The partnership with IBM and AMD was chosen for their advanced product roadmaps and ability to supply GPU accelerators at the speed needed for Zyphra’s innovation. This marks the first major dedicated training cluster on IBM Cloud using AMD Instinct MI300X GPUs along with Pensando Pollara 400 AI NICs and Ortano DPUs. Zyphra began using the system in early September, with further expansion planned for 2026.
Zyphra intends to use this infrastructure to develop foundation models across language, vision, and audio domains. These models will support Maia, a general-purpose superagent designed to improve productivity for enterprise knowledge workers. Both IBM and AMD plan to scale resources as Zyphra’s needs grow.
Krithik Puthalath, CEO and Chairman of Zyphra, said: “This collaboration marks the first time AMD’s full-stack training platform—spanning compute through networking—has been successfully integrated and scaled on IBM Cloud, and Zyphra is honored to lead the way in developing frontier models with AMD silicon on IBM Cloud. We’re excited to partner with IBM and AMD to power the next era of open-source, enterprise superintelligence.”
IBM previously announced its intention to deploy AMD Instinct MI300X accelerators as a service on its cloud platform. According to Alan Peacock, GM of IBM Cloud: “Scaling AI workloads faster and more efficiently is a key differentiator in achieving ROI for established enterprises and emerging companies alike. We are delighted to support Zyphra’s strategic roadmap as we collaborate with AMD to deliver scalable, economical AI infrastructure that can accelerate Zyphra’s model training.”
Philip Guido, EVP and Chief Commercial Officer at AMD added: “The IBM and AMD collaboration delivers innovation at the speed and scale clients demand, representing a new standard in AI infrastructure. By combining IBM enterprise cloud expertise with AMD leadership in high-performance computing and AI acceleration, we are supporting Zyphra’s pioneering work in multimodal and inference-efficient AI, enabling organizations everywhere to build smarter businesses and unlock AI solutions that drive real-world outcomes.”
IBM and AMD are also working together on quantum-centric supercomputing architectures by leveraging both companies’ strengths in quantum computing software (IBM) and high-performance computing hardware (AMD).
More information about the collaboration can be found at https://www.ibm.com/products/gpu-ai-accelerator/amd
IBM provides hybrid cloud services across more than 175 countries. Its technology supports governments and corporations across sectors such as financial services, telecommunications, healthcare, helping them manage data insights securely while reducing costs.
